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Arterial Blood Gases in Normal Subjects at 2240 Meters Above Sea Level: Impact of Age, Gender, and Body Mass Index
Cid-Juárez, Silvia; Téllez-Navarrete, Norma A.; Bautista-Bernal, Anaid; León-Gómez, Pablo; Salas-Escamilla, Isabel; Gochicoa-Rangel, Laura; Pérez-Padilla, Rogelio.
Affiliation
  • Cid-Juárez, Silvia; National Institute of Respiratory Diseases. MX
  • Téllez-Navarrete, Norma A.; National Institute of Respiratory Diseases. MX
  • Bautista-Bernal, Anaid; National Institute of Respiratory Diseases. MX
  • León-Gómez, Pablo; National Institute of Respiratory Diseases. MX
  • Salas-Escamilla, Isabel; National Institute of Respiratory Diseases. MX
  • Gochicoa-Rangel, Laura; National Institute of Respiratory Diseases. MX
  • Pérez-Padilla, Rogelio; National Institute of Respiratory Diseases. MX
Rev. invest. clín ; Rev. invest. clín;75(1): 29-36, Jan.-Feb. 2023. tab, graf
Article in En | LILACS-Express | LILACS | ID: biblio-1450100
Responsible library: MX1.1
ABSTRACT
ABSTRACT Background The values of arterial blood gases (ABG) change with altitude above sea level; empirical verification is essential because ventilatory acclimatization varies with ethnicity and a population's adaptation. Objective The aim of the study was to describe ABG in a healthy population residing at 2,240 meters above sea level, to identify the mean level of alveolar ventilation (PaCO2), and to know whether a progressive increase in PaCO2 occurs with age and the impact of increasing body mass index (BMI). Methods We conducted a cross-sectional study in a referral center for respiratory diseases in Mexico City. Associations among variables with correlation coefficient and regression models of PaO2, SaO2, and P(A-a)O2 as dependent variables as a function of age, BMI, minute ventilation, or breathing frequency were explored. Results Two hundred and seventeen healthy subjects were evaluated with a mean age of 40 ± 15 years, mean of the PaO2 was 71 ± 6 mmHg, SaO2 94% ± 1.6%, PaCO2 30.2 ± 3.4 mmHg, HCO3 20 ± 2 mmol/L, BE-2.9 ± 1.9 mmol/L, and the value of pH was 7.43 ± 0.02. In a linear regression, the main results were PaO2 = 77.5-0.16*age (p < 0.0001) and with aging P(A-a)O2 tended to increase 0.12 mmHg/year. PaCO2 in women increased with age by 0.075 mmHg/year (p = 0.0012, PaCO2 =26.3 + 0.075*age). SaO2 and PaO2 decreased significantly in women with higher BMI 0.14% and 0.52 mmHg per kg/m2, (p = 0.004 and 0.002 respectively). Conclusion Mean PaCO2 was 30.7 mmHg, implying a mean alveolar ventilation of around 30% above that at sea level.
Key words

Full text: 1 Collection: 01-internacional Database: LILACS Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Determinantes_sociais_saude Language: En Journal: Rev. invest. clín Journal subject: MEDICINA Year: 2023 Document type: Article Affiliation country: Mexico Country of publication: Mexico

Full text: 1 Collection: 01-internacional Database: LILACS Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Determinantes_sociais_saude Language: En Journal: Rev. invest. clín Journal subject: MEDICINA Year: 2023 Document type: Article Affiliation country: Mexico Country of publication: Mexico