Primary culture macrophages from fish as potential experimental model in toxicity studies with multiwalled carbon nanotubes
Acta sci., Biol. sci
; 43: e52612, 2021. graf, ilus
Article
in English
| LILACS, VETINDEX
| ID: biblio-1460984
Responsible library:
BR68.1
Localization: BR68.1
ABSTRACT
Multiwalled carbon nanotube (MWCNT) has been broadly used in several sectors of society. This material when exposed to the environment might reach the aquatic animals and cause toxic effects. Here, it was evaluated the MWCNTs toxicity in melanomacrophages primary culture that was submitted to 1 µ gm L-1 MWCNTs for 24 hours. After exposition to MWCNT, 48 and 59% liver and spleen melanomacrophages were healthy, respectively. The control group presented 85% viability. Phagocytosis activity of melanomacrophages was observed by presence of black inclusions in cytoplasm. The findings indicate MWCNT was cytotoxic to melanomacrophages, where its release and effect into aquatic environment must be more studied. Finally, the melanomacrophages present large potential as experimental model for evaluation of carbon-based nanomaterial toxicity.
Full text:
Available
Database:
LILACS
/
VETINDEX
Main subject:
Phagocytosis
/
Nanotubes, Carbon
/
Fishes
/
Macrophages
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta sci., Biol. sci
Year:
2021
Document type:
Article
Institution/Affiliation country:
Universidade Federal de São João Del Rei/BR