Snake venom L-amino acid oxidases: an overview on their antitumor effects
J. venom. anim. toxins incl. trop. dis
; 20: 1-7, 04/02/2014. tab, ilus
Article
in English
| LILACS, VETINDEX
| ID: biblio-1484558
Responsible library:
BR68.1
Localization: BR68.1
ABSTRACT
The L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and have been widely studied due to their widespread presence and various effects, such as apoptosis induction, cytotoxicity, induction and/or inhibition of platelet aggregation, hemorrhage, hemolysis, edema, as well as antimicrobial, antiparasitic and anti-HIV activities. The isolated and characterized snake venom LAAOs have become important research targets due to their potential biotechnological applications in pursuit for new drugs of interest in the scientific and medical fields. The current study discusses the antitumor effects of snake venom LAAOs described in the literature to date, highlighting the mechanisms of apoptosis induction proposed for this class of proteins.
Full text:
Available
Database:
LILACS
/
VETINDEX
Main subject:
Oxidoreductases
/
Poisons
/
L-Amino Acid Oxidase
Limits:
Animals
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Year:
2014
Document type:
Article
Institution/Affiliation country:
Universidade de São Paulo/BR