Hematological alterations during experimental canine infection by Trypanosoma cruzi / Alterações hematológicas durante a infecção canina experimental por Trypanosoma cruzi
Rev. Bras. Parasitol. Vet. (Online)
; 21(2): 151-156, abr.-jun. 2012.
Article
in English
| LILACS, VETINDEX
| ID: biblio-1487793
Responsible library:
BR68.1
Localization: BR68.1
ABSTRACT
To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosoma cruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Simultaneously, we observed anemia, leukocytosis and lymphocytosis. Also,we describe hematological alterations and clinical signs that were positively correlated with the parasitemia during the experimental infection with the three strains of T.cruzi, and demonstrate that experimental infection of Beagle is a trustworthy model for Chagas disease.
RESUMO
Para confirmar que cães Beagle são um bom modelo para doença de Chagas, foram avaliadas as alterações hematológicas durante as fases aguda e crônica em cães Beagle infectados com as cepas Y, Berenice-78 (Be-78) e ABC de Trypanosomacruzi, correlacionando os sinais clínicos com a curva de parasitemia. Foi demonstrado que a fase aguda da infecção foi marcada por letargia e perda de apetite. Simultaneamente, observou-se anemia, leucocitose e linfocitose. Ainda, foram descritas alterações hematológicas e sinais clínicos positivamente correlacionados com a parasitemia durante a infecção experimental com as três cepas de T.cruzi estudadas, demonstrando que a infecção em cães Beagle constitui um modelo fidedigno para a doença de Chagas.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Zoonoses
Database:
LILACS
/
VETINDEX
Main subject:
Trypanosoma cruzi
/
Chagas Disease
/
Parasitemia
/
Anemia
/
Leukocytosis
/
Lymphocytosis
Limits:
Animals
Language:
English
Journal:
Rev. Bras. Parasitol. Vet. (Online)
Year:
2012
Document type:
Article
Institution/Affiliation country:
Federal University of Minas Gerais/BR
/
Federal University of Ouro Preto/BR
/
Federal University of Rio Grande do Norte/BR
/
Federal University of Uberlândia/BR
/
Universidade de São Paulo/BR