Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure
Biol. Res
; 54: 43-43, 2021. ilus
Article
in En
| LILACS
| ID: biblio-1505826
Responsible library:
CL1.1
ABSTRACT
BACKGROUND:
Chronic heart failure (CHF) is a global health problem. Increased sympathetic outflow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several studies showed that activation of the renin-angiotensin system (RAS) play a key role in CHF pathophysiology. Interestingly, potassium (K+) supplemented diets showed promising results in normalizing RAS axis and autonomic dysfunction in vascular diseases, lowering cardiovascular risk. Whether subtle increases in dietary K+ consumption may exert similar effects in CHF has not been previously tested. Accordingly, we aimed to evaluate the effects of dietary K+ supplementation on cardiorespiratory alterations in rats with CHF.METHODS:
Adult male Sprague-Dawley rats underwent volume overload to induce non-ischemic CHF. Animals were randomly allocated to normal chow diet (CHF group) or supplemented K+ diet (CHF+K+ group) for 6 weeks. Cardiac arrhythmogenesis, sympathetic outflow, baroreflex sensitivity, breathing disorders, chemoreflex function, respiratory- cardiovascular coupling and cardiac function were evaluated.RESULTS:
Compared to normal chow diet, K+ supplemented diet in CHF significantly reduced arrhythmia incidence (67.8 ± 15.1 vs. 31.0 ± 3.7 events/hour, CHF vs. CHF+K+), decreased cardiac sympathetic tone (ΔHR to propranolol - 97.4 ± 9.4 vs. - 60.8 ± 8.3 bpm, CHF vs. CHF+K+), restored baroreflex function and attenuated irregular breathing patterns. Additionally, supplementation of the diet with K+ restores normal central respiratory chemoreflex drive and abrogates pathological cardio-respiratory coupling in CHF rats being the outcome an improved cardiac function.CONCLUSION:
Our findings support that dietary K+ supplementation in non-ischemic CHF alleviate cardiorespiratory dysfunction.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Heart Failure
Limits:
Animals
Language:
En
Journal:
Biol. Res
Journal subject:
BIOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
Chile
Country of publication:
Chile