Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT?
Braz. j. oral sci
; 22: e238998, Jan.-Dec. 2023. tab
Article
in English
| LILACS, BBO - Dentistry
| ID: biblio-1509519
Responsible library:
BR218.1
ABSTRACT
Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment for many diseases; however, it can induce complications such as Oral Mucositis (OM) and Graft-versus- Host Disease (GVHD). The neutrophil-lymphocyte ratio (NLR) is a peripheral biomarker of systemic inflammation and an independent prognostic factor for several inflammatory diseases. Aim:
This study aimed to evaluate the association of NLR with OM and GVHD in patients undergoing allogeneic HSCT.Methods:
Patients who underwent allogeneic HSCT at the Bone Marrow Transplant Service of the Hospital de Clínicas Complex of the Federal University of Paraná were included in the study. Socio-demographic data and blood counts were collected from patients' medical records. The NLR was calculated and associated with OM and GVHD.Results:
45 patients were included in the study. Although NLR was higher in patients with OM and oral GVHD, no statistical difference was observed, and no relationship between OM and GVHD with NLR could be stated.Conclusion:
Although both OM and GVHD are associated with an inflammatory response as well as the immune system, it was not associated with NLR. Further investigation considering other variables related to HSCT might find possible associations, as it could favor patient management and preventionSubject(s)
Full text:
Available
Collection:
International databases
Database:
BBO - Dentistry
/
LILACS
Main subject:
Stomatitis
/
Lymphocytes
/
Hematopoietic Stem Cell Transplantation
/
Graft vs Host Disease
/
Neutrophils
Type of study:
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. oral sci
Journal subject:
Dentistry
Year:
2023
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Paraná/BR