Your browser doesn't support javascript.
loading
Ancestry and self-reported race in Brazilian breast cancer women
Vieira, René Aloisio da Costa; SantAnna, Débora; Laus, Ana Carolina; Reis, Rui Manuel.
Affiliation
  • Vieira, René Aloisio da Costa; Hospital de Câncer de Barretos. Molecular Oncology Research Center. Barretos. BR
  • SantAnna, Débora; Hospital de Câncer de Barretos. Molecular Oncology Research Center. Barretos. BR
  • Laus, Ana Carolina; Hospital de Câncer de Barretos. Molecular Oncology Research Center. Barretos. BR
  • Reis, Rui Manuel; Hospital de Câncer de Barretos. Molecular Oncology Research Center. Barretos. BR
Rev. Assoc. Med. Bras. (1992, Impr.) ; 69(12): e20230767, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1521501
Responsible library: BR1.1
ABSTRACT
SUMMARY

OBJECTIVE:

This study aimed to evaluate the association between self-reported race/color and ancestry in Brazilian patients with breast cancer.

METHODS:

This was an observational, transversal, epidemiological study, evaluating race and ancestry in 1,127 patients with breast cancer. For genetic ancestry, a 46-AIM-INDEL panel was used. The ancestral profile was evaluated with the Structure v.2.3.3 software. Descriptive statistics were performed. To assess differences between race and ancestry, an analysis of variance with Bonferoni adjustment was used.

RESULTS:

The race distribution was 77.7% white, 17.6% brown, 4.1% black, 0.4% yellow, and 0.3% cafuse. The African ancestry proportion was significantly (p<0.001) more evident in black [0.63±0.21 (0.17-0.96)], followed by brown [0.25±0.16 (0.02-0.70)], and less frequent in white skin color. The European ancestry proportion was significantly (p<0.001) higher in white [0.72±0.17 (0.02-0.97)], followed by brown [0.57±0.19 (0.12-0.92)], yellow [0.27±0.31 (0.12-0.620], and black [0.24±0.19 (0.02-0.72)]. The Asiatic ancestry proportion is significantly (p<0.001) higher in yellow [0.48±0.51 (0.04-0.93)]. The Amerindian ancestry proportion frequency was the least frequent in all groups, and cafuse patients did not express differences between all race groups. The brown race group presented differences in African and European ancestry.

CONCLUSION:

Although we found many similarities between white European ancestry, black African ancestry, and yellow Asian ancestry, there is great miscegenation between patients. Although they can be labeled as having one race, they do present many ancestral genes that would allow their inclusion in another race group.


Full text: Available Collection: International databases Database: LILACS Country/Region as subject: South America / Brazil Language: English Journal: Rev. Assoc. Med. Bras. (1992, Impr.) Journal subject: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicine Year: 2023 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Hospital de Câncer de Barretos/BR

Full text: Available Collection: International databases Database: LILACS Country/Region as subject: South America / Brazil Language: English Journal: Rev. Assoc. Med. Bras. (1992, Impr.) Journal subject: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicine Year: 2023 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Hospital de Câncer de Barretos/BR
...