Community-based progress indicators for prevention of mother-to-child transmission and mortality rates in HIV-exposed children in rural Mozambique
BMC public health (Online)
; 21(1): 1-12, 2021. tab, ilus, graf
Article
in English
| RSDM
| ID: biblio-1524953
Responsible library:
MZ1.1
ABSTRACT
Background:
Eliminating mother-to-child HIV-transmission (EMTCT) implies a case rate target of new pediatric HIV-infections< 50/100,000 live-births and a transmission rate < 5%. We assessed these indicators at community-level in Mozambique, where MTCT is the second highest globally..Methods:
A cross-sectional household survey was conducted within the Manhiça Health Demographic Surveillance System in Mozambique (October 2017-April 2018). Live births in the previous 4 years were randomly selected, and mother/child HIV-status was ascertained through documentation or age-appropriate testing. Estimates on prevalence and transmission were adjusted by multiple imputation chained equation (MICE) for participants with missing HIV-status. Retrospective cumulative mortality rate and risk factors were estimate by Fine-Gray model.Results:
Among 5000 selected mother-child pairs, 3486 consented participate. Community HIV-prevalence estimate in mothers after MICE adjustment was 37.6% (95%CI35.8-39.4%). Estimates doubled in adolescents aged < 19 years (from 8.0 to 19.1%) and increased 1.5-times in mothers aged < 25 years. Overall adjusted vertical HIV-transmission at the time of the study were 4.4% (95% CI3.1-5.7%) in HIV-exposed children (HEC). Pediatric case rate-infection was estimated at 1654/100,000 live-births. Testing coverage in HEC was close to 96.0%; however, only 69.1% of them were tested early(< 2 months of age). Cumulative child mortality rate was 41.6/1000 live-births. HIV-positive status and later birth order were significantly associated with death. Neonatal complications, HIV and pneumonia...
Full text:
Available
Collection:
National databases
/
MZ
Database:
RSDM
Main subject:
Pregnancy Complications, Infectious
/
HIV Infections
Limits:
Child
/
Female
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Humans
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Male
Country/Region as subject:
Africa
Language:
English
Journal:
BMC public health (Online)
Year:
2021
Document type:
Article
Institution/Affiliation country:
Barcelona Institute for Global Health/ES
/
Centro de investigação em saúde de manhiça/MZ
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Division of global HIV and tuberculosis/US
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Division of global HIV and tuberculosis, U.S. centers for disease control and prevention/MZ
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Instituto nacional de saúde/MZ
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Manhiça district health services/MZ
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Ministério da saúde de moçambique/MZ