Elevated serum IL-6 levels predict treatment interruption in patients with moderate to severe psoriasis: a 6-year real-world cohort study
An. bras. dermatol
; 99(1): 34-42, Jan.-Feb. 2024. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1527686
Responsible library:
BR1.1
ABSTRACT
Abstract Background:
Real-world, primary data on the treatment of psoriasis are scarce, especially concerning the role of soluble biomarkers as outcome predictors.Objective:
The authors evaluated the utility of Th1/Th17 serum cytokines along with clinical characteristics as predictors of drug survival in the treatment of psoriasis.Methods:
The authors consecutively included participants with moderate to severe psoriasis who were followed up for 6 years. Baseline interferon-α, tumor necrosis factor-α, and inter-leukin (IL)-2, IL-4, IL-6, IL-10, and IL-17A were measured using a cytometric bead array; clinical data were assessed. The authors calculated hazard ratios (HRs) for drug survival using a Cox proportional hazards model.Results:
The authors included 262 patients, most of whom used systemic immunosuppressants or biologics. In the multivariate model, poor quality of life measured by the Dermatology Life Quality Index (HR = 1.04; 95% CI 1.01-1.07; p = 0.012) and elevated baseline IL-6 (HR = 1.99; 95% CI 1.29-3.08; p = 0.002) were associated with treatment interruption. Studylimitations:
The main limitation of any cohort study is the presence of confounders that could not be detected in clinical evaluation.Conclusions:
Poor quality of life and elevated baseline serum IL-6 level predicted treatment interruption in patients with moderate to severe psoriasis. Although IL-6 is not the most important mediator of the inflammatory pathway in the skin environment, it is an interesting biomarker candidate for predicting psoriasis treatment response.
Full text:
Available
Collection:
International databases
Database:
LILACS
Type of study:
Etiology study
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Observational study
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Prognostic study
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Risk factors
Aspects:
Patient-preference
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2024
Document type:
Article
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Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
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Hospital Universitário de Brasília/BR
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Universidade Federal de Uberlândia/BR
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Universidade de Brasília/BR