Perinatal N(G)-Nitro-L-arginine methyl ester administration decreases anxiety- and depression-like behaviors in adult mice
Einstein (Säo Paulo)
; 21: eAO0302, 2023. tab, graf
Article
in En
|
LILACS-Express
| LILACS
| ID: biblio-1528572
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Objective:
We hypothesized that perinatal manipulations of the nitrergic system would affect adult animal behaviors.Methods:
We tested this hypothesis by perinatally administering N(G)-Nitro-L-arginine methyl ester (L-NAME), a non-specific antagonist of nitric oxide synthase for 15 days and assessed anxiety- and depression-like behaviors in adult mice. At 70 days of age, the mice were subjected to a battery of tests consisting of the open-field, light/dark box, forced swim, and tail-flick tests. The tests were performed at two-day intervals, and the order of the tests within the battery was determined according to the progressive invasiveness degree.Results:
L-NAME-treated animals exhibited decreased anxiety-like behavior in the light/dark box and open field tests, with no change in locomotor activity. Additionally, they demonstrated decreased depression-like behavior in the forced swim test and no change in pain perception in the tail-flick test.Conclusion:
The nitrergic system is possibly involved in neural circuitry development that regulates behaviors since blocking perinatal nitric oxide production decreases anxiety- and depression-like behaviors in adult mice.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Language:
En
Journal:
Einstein (Säo Paulo)
Journal subject:
MEDICINA
Year:
2023
Document type:
Article
/
Project document
Affiliation country:
Brazil
/
Egypt
Country of publication:
Brazil