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Single Nucleotides Polymorphisms in COX2 Gene and their Association with Signs and Symptoms of Teething - A Pilot Study
Mauta, Alana Gonçalvez; Reis, Caio Luiz Bitencourt; Teodoro, Vinicius Broska; Madalena, Isabela Ribeiro; Kirschneck, Christian; Proff, Peter; Paza, Aleysson Olimpio; Baratto-Filho, Flares; Oliveira, Daniela Silva Barroso de; Küchler, Erika Calvano; Brancher, João Armando.
Affiliation
  • Mauta, Alana Gonçalvez; Positivo University. School of Health Sciences. Curitiba. BR
  • Reis, Caio Luiz Bitencourt; Federal University of Alfenas. School of Dentistry. Department of Clinic and Surgery. Alfenas. BR
  • Teodoro, Vinicius Broska; Positivo University. School of Health Sciences. Curitiba. BR
  • Madalena, Isabela Ribeiro; Positivo University. School of Health Sciences. Curitiba. BR
  • Kirschneck, Christian; University Hospital Regensburg. Regensburg. DE
  • Proff, Peter; University Hospital Regensburg. Regensburg. DE
  • Paza, Aleysson Olimpio; University of the Region of Joinville. Departament of Dentistry. Joinville. BR
  • Baratto-Filho, Flares; University of the Region of Joinville. Departament of Dentistry. Joinville. BR
  • Oliveira, Daniela Silva Barroso de; Federal University of Alfenas. School of Dentistry. Department of Clinic and Surgery. Alfenas. BR
  • Küchler, Erika Calvano; University Hospital Regensburg. Regensburg. DE
  • Brancher, João Armando; Positivo University. School of Health Sciences. Curitiba. BR
Pesqui. bras. odontopediatria clín. integr ; 23: e210244, 2023. tab, graf
Article in En | LILACS, BBO | ID: biblio-1529121
Responsible library: BR1264.1
ABSTRACT
ABSTRACT

Objective:

To investigate the association between single nucleotide polymorphisms in the COX2 gene (rs689466 and rs5275) and local and systemic signs and symptoms of teething. Material and

Methods:

Forty-four pairs of mothers-babies/toddlers were included. Erupted primary teeth were evaluated during clinical examination. Local and systemic signs and symptoms of teething were obtained from mothers' reporting via anamnesis. Samples of buccal cells were retrieved for DNA genotyping using real-time PCR. The T-test, Chi-square test, logistic regression, and haplotype analyses were applied.

Results:

Almost all mothers (95.5%) reported at least one local or systemic sign and symptom of teething. The most common was increased salivation (79.5%), diarrhea (72.3 %), and fever (70.5 %). The mean number of signs and symptoms per child was higher in boys than girls (mean = 5.1; SD= 1.5; p=0.008). Sleep disturbance (p=0.03) and loss of appetite (p=0.05) were more reported in boys. The rs689466 and rs5275 were not associated with signs and symptoms of teething (p>0.05).

Conclusion:

The single nucleotide polymorphisms in the COX2 gene (rs689466 and rs5275) were not associated with local and systemic signs and symptoms of teething.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: BBO / LILACS Main subject: Sleep Wake Disorders / Tooth, Deciduous / Tooth Eruption / Polymorphism, Single Nucleotide Type of study: Diagnostic_studies / Risk_factors_studies Limits: Child, preschool / Female / Humans / Infant / Male Language: En Journal: Pesqui. bras. odontopediatria clín. integr Journal subject: ODONTOLOGIA Year: 2023 Document type: Article Affiliation country: Brazil / Germany Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: BBO / LILACS Main subject: Sleep Wake Disorders / Tooth, Deciduous / Tooth Eruption / Polymorphism, Single Nucleotide Type of study: Diagnostic_studies / Risk_factors_studies Limits: Child, preschool / Female / Humans / Infant / Male Language: En Journal: Pesqui. bras. odontopediatria clín. integr Journal subject: ODONTOLOGIA Year: 2023 Document type: Article Affiliation country: Brazil / Germany Country of publication: Brazil