Abordaje farmacológico integral del tratamiento de la reactivación de la enfermedad de Chagas en pacientes con HIV/sida / Comprehensive pharmacological approach to treatment of reactivation of Chagas disease in patients with HIV / AIDS
Actual. SIDA. infectol
; 24(91): 1-5, 20160000.
Article
in Spanish
| LILACS, BINACIS
| ID: biblio-1531414
Responsible library:
AR392.1
RESUMEN
La reactivación de la enfermedad de Chagas en pacientes HIV/sida con bajos recuentos de LTCD4 es un problema que complica el manejo de ambas infecciones. Se dispone actualmente de dos fármacos antichagá-sicos con eficacia debidamente documentada en pacientes no coinfecta-dos. Sin embargo, existe poca evidencia y experiencia clínica en cuanto a la eficacia y la seguridad del tratamiento integral en este grupo de pa-cientes susceptibles de sufrir distintos efectos adversos a fármacos y con altas tasas de mortalidad a corto y mediano plazo. En el presente artículo se describen las consideraciones (en especial las que atañen a la poten-ciación de efectos adversos y la posibilidad de interacciones farmacoló-gicas), que deben tenerse en cuenta acerca del tratamiento antirretrovi-ral, antichagásico y anticonvulsivante conjunto y los esquemas terapéu-ticos más adecuados para pacientes coinfectados
ABSTRACT
Reactivation of Chagas Disease in patients HIV/AIDS with low counts LTCD4 is a problem that complicates management of both infections. There are currently two antiparasitic drugs properly documented efficacy in patients non-co-infected patients. However, there is little evidence and clinical experience regarding the efficacy and safety of an integral treatment in this group of patients, who are susceptible of suffering diverse adverse drug reactions and who have high mortality rates both in the short and long-term. In this article we describe the considerations (especially those related to adverse effects and possibility of pharmacological interactions) that must be taken into account during the combined antiretroviral, antichagasic and anticonvulsant treatment, as well as the most convenient treatment for patients described co-infected.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Chagas Disease
/
Neglected Diseases
Database:
BINACIS
/
LILACS
Main subject:
HIV Infections
/
Chagas Disease
/
Antiretroviral Therapy, Highly Active
/
Drug Interactions
/
Latent Infection
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Actual. SIDA. infectol
Journal subject:
Medicine
/
SINDROIMUNE IMUN ADQUIRIDAUIRIDAUIRIDA
Year:
2016
Document type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad de Buenos Aires/AR