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Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review
Lopes-Santos, Gabriela; Marques, Najara Gomes de Oliveira; Tjioe, Kellen Cristine; Oliveira, Denise Tostes.
Affiliation
  • Lopes-Santos, Gabriela; Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Cirurgia, Estomatologia, Patologia e Radiologia. Bauru. BR
  • Marques, Najara Gomes de Oliveira; Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Cirurgia, Estomatologia, Patologia e Radiologia. Bauru. BR
  • Tjioe, Kellen Cristine; Augusta University. Georgia Cancer Center. Augusta. US
  • Oliveira, Denise Tostes; Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Cirurgia, Estomatologia, Patologia e Radiologia. Bauru. BR
Acta cir. bras ; 39: e390824, 2024. tab, graf, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1533356
Responsible library: BR68.1
Localization: BR68.1
ABSTRACT

Purpose:

This systematic review analyzed the clinical behavior and odds of malignancy of the palatal recurrent pleomorphic adenomas.

Methods:

Systematic review of patients with recurrent pleomorphic adenoma arising in the palate. Database search MEDLINE, Scopus, Web of Science, Cochrane, EMBASE, Virtual Health Library, Google Scholar, and OpenGrey. A binomial logistic regression was performed to assess the odds of detecting recurrence five, 10 and 20 years after the treatment of primary tumor.

Results:

Thirteen studies (n = 18 patients) out of 336 were included. The recurrent pleomorphic adenoma in palate was more common in females (61.6%), average age was 49 years old (range 9-73 years old). Four patients progressed to malignant transformation. The odds ratio (OR) of detecting a recurrence at 10 (OR = 5.57; 95% confidence interval - 95%CI 1.13-27.52), and 20 years (OR = 18.78; 95%CI 3.18-110.84) after treatment of primary pleomorphic adenoma was significantly higher than at one-year follow-up.

Conclusions:

The recurrence of pleomorphic adenoma in palate remains a rare event of late occurrence. It mainly affects middle-aged female and carries a risk of malignant transformation. Although uncommon, patients with palatal pleomorphic adenoma should be warned about the possibility of recurrence or malignant transformation of tumor at advanced ages.
Subject(s)


Full text: Available Collection: International databases Database: LILACS / VETINDEX Main subject: Palate / Salivary Glands / Adenoma, Pleomorphic / Neoplasms Language: English Journal: Acta cir. bras Journal subject: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Year: 2024 Document type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Augusta University/US / Universidade de São Paulo/BR

Full text: Available Collection: International databases Database: LILACS / VETINDEX Main subject: Palate / Salivary Glands / Adenoma, Pleomorphic / Neoplasms Language: English Journal: Acta cir. bras Journal subject: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Year: 2024 Document type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Augusta University/US / Universidade de São Paulo/BR
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