nteraction between FAK/αB-crystalline is important for viability of the glioblastoma cells
Braz. J. Pharm. Sci. (Online)
; 60: e23380, 2024. graf
Article
in English
| LILACS
| ID: biblio-1533983
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
Abstract Glioblastoma multiforme is a tumor of the central nervous system. Focal Adhesion Kinase (FAK) and αB-crystalline are two proteins involved in glioblastoma development. In this study, we investigated whether the FAK/αB-crystalline interaction is important for glioblastoma cells, we aimed to investigate the interaction of these two proteins in the glioblastoma multiforme cell line U87-MG. Two peptides named FP01 peptide (derived from αB-crystalline) and FP02 peptide (derived from FAK) were synthesized for this study. Treatment of U87-MG with the peptides FP01 and FP02 in the concentration at 50 µM reduced the viability cellular to around 41% and 51%, respectively. Morphological alterations in the cells treated with the peptides when compared to the control were observed. This study suggests that the interaction between FAK and αB-crystalline is important for the viability of glioblastoma cells
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Peptides
/
Cells
/
Glioblastoma
/
Focal Adhesion Protein-Tyrosine Kinases
/
Neoplasms
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2024
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Alfenas/BR
/
Universidade Federal de Juiz de Fora/BR