SD bioline malaria rapid diagnostic test performance and time to become negative after treatment of malaria infection in southwest Nigerian children
Ann. afr. med
; 22(4): 470-460, 2023. figures, tables
Article
in English
| AIM (Africa)
| ID: biblio-1537705
Responsible library:
CG1.1
ABSTRACT
Context and Aim:
Given the challenges of microscopy, we compared its performance with SD Bioline malaria rapid diagnostic test (MRDT) and polymerase chain reaction (PCR) and evaluated the time it took for positive results to become negative after treatment of children with acute uncomplicated malaria. Subjects andMethods:
We present the report of 485 participants with complete MRDT, microscopy, and PCR data out of 511 febrile children aged 359 months who participated in a cohort study over a 12 month period in rural and urban areas of Ibadan, Nigeria. MRDT positive children received antimalaria and tested at every visit over 28 days. Speciation was also carried out by PCR.Results:
With microscopy as the gold standard, SD-Bioline™ had 95.2% sensitivity, 66.4% specificity, 67.5% positive predictive value (PPV), and 94.9 negative predictive value (NPV), while with PCR the findings were 84.3% sensitivity, 66.5% specificity, 72.7% PPV, and 80.1% NPV. PCR speciation of malaria parasites revealed 91.6% Plasmodium falciparum, 18.9% Plasmodium malariae, and 4.4% Plasmodium ovale. Among the 47 children with P. malariae infections, 66.0% were coinfected with P. falciparum, while 54.6% cases of P. ovale occurred as coinfections with P. falciparum. The median time to a negative MRDT was 23.2 days, while the median time to a negative malaria microscopy was 3.8 days. The two survival curves were significantly different.Conclusions:
The SD BiolineTM MRDT performed well, with remarkable persistence of rapid test-positive for an average of 23 days post treatment. The prevalence of P. malaria is somewhat greater than expected.
Fulltext
- https://journals.lww.com/aoam/fulltext/2023/22040/sd_bioline_malaria_rapid_diagnostic_test.11.aspx
- https://indexmedicus.afro.who.int/iah/fulltextSD bioline malaria rapid diagnostic test performance and time to become negative after treatment of malaria infection in southwest Nigerian children_Orimadegun/.pdf
- https://fi-admin.bvsalud.org/document/view/2uz5d
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Malaria
/
Neglected Diseases
Database:
AIM (Africa)
Main subject:
Sensitivity and Specificity
/
Malaria
Limits:
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
Ann. afr. med
Year:
2023
Document type:
Article
Institution/Affiliation country:
Department of Pharmacology, Babcock University, Ogun State, Nigeria/NG
/
Epidemiology and Biostatistics, College of Medicine/NG
/
Institute of Child Health, College of Medicine/NG
/
London School of Tropical Medicine and Hygiene, London, United Kingdom/GB
/
Malaria Consortium Regional Office for Africa, Kampala, Uganda/UG
/
Paediatrics College of Medicine/NG
/
Pharmacology and Therapeutics, College of Medicine/NG