An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus
J. venom. anim. toxins incl. trop. dis
; 30: e20230063, 2024. tab, graf
Article
in English
| LILACS, VETINDEX
| ID: biblio-1550522
Responsible library:
BR68.1
Localization: BR68.1
ABSTRACT
Background:
In Colombia, several species of Buthidae scorpions belonging to the genera Centruroides and Tityus coexist, and their stings are considered life-threatening to humans because of their venom neurotoxins. Despite previous studies focusing on neurotoxins from these scorpion genera, little is known about the enzymes present in their venoms and their relationship with whole venom toxicity.Methods:
Here, using proteomic and biochemical protocols the enzymatic activities of the venoms of three Colombian scorpion species, C. margaritatus, T. pachyurus, and T. n. sp. aff. metuendus, were compared to establish the presence and absence of enzymes such as phospholipases, hyaluronidases, and proteases that could be related to venom toxicity.Results:
C. margaritatus was positive for hyaluronidases, T. n. sp. aff. metuendus for proteases, and T. pachyurus exhibited activity for all three mentioned enzymes.Conclusion:
This information provides valuable insights into the specific enzyme diversity of each species' venom and their potential role in venom toxicity, which could contribute to the development of better treatments and prevention strategies for scorpion envenomation.
Full text:
Available
Collection:
International databases
Database:
LILACS
/
VETINDEX
Main subject:
Scorpion Venoms
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Journal subject:
Toxicology
Year:
2024
Document type:
Article
Affiliation country:
Colombia
/
Mexico
Institution/Affiliation country:
Universidad Nacional Autónoma de México/MX
/
Universidad Tecnológica de Pereira/CO
/
Universidad del Cauca/CO