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Comparison of Efficacy and Safety of Midazolam versus Nitrous Oxide as Sedative Agents during Paediatric Dental Treatment: A Systematic Review / Comparison of Efficacy and Safety of Midazolam versus Nitrous Oxide as Sedative Agents during Paediatric Dental Treatment: A Systematic Review
Janiani, Palak; Gurunathan, Deepa.
Affiliation
  • Janiani, Palak; Saveetha Institute of Medical and Technical Sciences. Saveetha Dental College and Hospital. Department of Paediatric and Preventive Dentistry. Chennai. IN
  • Gurunathan, Deepa; Saveetha Institute of Medical and Technical Sciences. Saveetha Dental College and Hospital. Department of Paediatric and Preventive Dentistry. Chennai. IN
Pesqui. bras. odontopediatria clín. integr ; 24: e230043, 2024. tab, graf
Article in English | LILACS, BBO - Dentistry | ID: biblio-1550596
Responsible library: BR1264.1
Localization: 1519-0501-pboci-24-e230043.xml
ABSTRACT
ABSTRACT

Objective:

To identify and study the existing literature on the efficacy and safety of midazolam compared to inhalation of nitrous oxide in children undergoing dental treatment. Material and

Methods:

Electronic resources such as PubMed Central, Cochrane Database of Systematic Reviews, Lilacs, Science Direct, and SIGLE were thoroughly searched. The title scan was used to find randomised controlled trials reviewed for inclusion by reading the abstract. Studies comparing the sedative, behavioural, and anxiolytic effects and safety in children undergoing dental treatment under midazolam and nitrous oxide inhalation were included. The Cochrane Reviews system software, Revman 5.4.1, was used to assess the quality of the included studies.

Results:

11328 articles were identified by screening the electronic databases, of which 10906 were eliminated after titles were read and duplicates were removed. Ten full-text articles were examined, of which three were excluded as they did not match the eligibility criteria. Hence, a total of 7 studies were included. Midazolam and nitrous oxide inhalation were not statistically different in terms of the success of treatment and behaviour modification. However, midazolam showed a deeper level of sedation and resulted in amnesia in more children when compared to nitrous oxide sedation. All of the included studies were found to have a high risk of bias.

Conclusion:

Though all the studies included showed an increased risk of bias, midazolam and nitrous oxide inhalation seem equally effective sedative agents for controlling behaviour in children undergoing dental treatment. Midazolam shows a deeper sedation level when given orally and produces a higher rate of anterograde amnesia.
Subject(s)


Full text: Available Collection: International databases Database: BBO - Dentistry / LILACS Main subject: Midazolam / Dental Care for Children / Hypnotics and Sedatives / Nitrous Oxide Language: English Journal: Pesqui. bras. odontopediatria clín. integr Journal subject: Dentistry Year: 2024 Document type: Article Affiliation country: India Institution/Affiliation country: Saveetha Institute of Medical and Technical Sciences/IN

Full text: Available Collection: International databases Database: BBO - Dentistry / LILACS Main subject: Midazolam / Dental Care for Children / Hypnotics and Sedatives / Nitrous Oxide Language: English Journal: Pesqui. bras. odontopediatria clín. integr Journal subject: Dentistry Year: 2024 Document type: Article Affiliation country: India Institution/Affiliation country: Saveetha Institute of Medical and Technical Sciences/IN
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