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Effect of coenzyme Q10 supplementation on statin-related myopathic pain: a systematic review and meta-analysis of randomized controlled trials
Kelly, Francinny A; Siebel, Victoria M; Souza, Maria Eduarda E. Cavalcanti; Sudo, Renan Y; Moraes, Francisco Cezar A; Barros, Maria Luisa S; Lima, Pedro L; lopes, Lucca M; Leite, Marianna G; Lobo, Artur D; Laurinavicius, Antonio; Sousa, Marcio G; Souza, Jonathan.
Affiliation
  • Kelly, Francinny A; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Siebel, Victoria M; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Souza, Maria Eduarda E. Cavalcanti; Instituto Dante Pazzanese de Cardiologia. São Paulo. BO
  • Sudo, Renan Y; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Moraes, Francisco Cezar A; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Barros, Maria Luisa S; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Lima, Pedro L; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • lopes, Lucca M; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Leite, Marianna G; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Lobo, Artur D; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Laurinavicius, Antonio; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Sousa, Marcio G; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Souza, Jonathan; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
Circulation ; 149(Suppl)May 16, 2024.
Article in English | CONASS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1554725
Responsible library: BR79.1
ABSTRACT

INTRODUCTION:

Coenzyme Q10 (CoQ10) has shown promising results as an adjuvant therapy to statins. However, the efficacy of this agent is still unclear.

Hypothesis:

The use of CoQ10 mitigates statin-related myopathic pain.

METHODS:

PubMed, Embase, and Cochrane databases were searched for randomized controlled trials (RCTs) comparing CoQ10 supplementation with placebo in patients taking statins. A random-effects model was employed to compute the mean difference (MD) with 95% confidence interval (CI). Statistical analysis was performed using R software 4.3.1.

RESULTS:

A total of 5 studies and 227 patients were included, of whom 48% were randomized to CoQ10 supplementation. Compared with placebo, CoQ10 had no effects on pain severity score (MD -0.94; 95% CI -3.80 to 1.91; p=0.5), and pain intensity score (MD -1.51; 95% CI -4.09 to 1.06; p = 0.2). Moreover, no association was found with low density lipoprotein cholesterol levels (MD -0.07; 95% CI -0.47 to 0.34; p = 0.7).

CONCLUSIONS:

In this meta-analysis of 5 RCTs, supplementation with CoQ10 did not yield statistically significant results. These findings suggest that CoQ10 has no impact on statin-related myopathic pain.

Full text: Available Collection: National databases / Brazil Database: CONASS / Sec. Est. Saúde SP / SESSP-IDPCPROD Language: English Journal: Circulation Year: 2024 Document type: Article / Congress and conference Institution/Affiliation country: Instituto Dante Pazzanese de Cardiologia/BO / Instituto Dante Pazzanese de Cardiologia/BR

Full text: Available Collection: National databases / Brazil Database: CONASS / Sec. Est. Saúde SP / SESSP-IDPCPROD Language: English Journal: Circulation Year: 2024 Document type: Article / Congress and conference Institution/Affiliation country: Instituto Dante Pazzanese de Cardiologia/BO / Instituto Dante Pazzanese de Cardiologia/BR
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