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Establishment and application of a new 4/6 infarct nephrectomy rat model for moderate chronic kidney disease
Sugai, Kazuhisa; Hirano, Momoko; Oda, Asahi; Fujisawa, Masahiko; Shono, Saori; Ishioka, Katsumi; Tamura, Tomoyoshi; Katsumata, Yoshinori; Sano, Motoaki; Kobayashi, Eiji; Hakamata, Yoji.
Affiliation
  • Sugai, Kazuhisa; Nippon Veterinary and Life Science University. School of Veterinary Nursing and Technology. Department of Basic Science. Tokyo. JP
  • Hirano, Momoko; Nippon Veterinary and Life Science University. School of Veterinary Nursing and Technology. Department of Basic Science. Tokyo. JP
  • Oda, Asahi; Nippon Veterinary and Life Science University. School of Veterinary Nursing and Technology. Department of Basic Science. Tokyo. JP
  • Fujisawa, Masahiko; Nippon Veterinary and Life Science University. School of Veterinary Nursing and Technology. Department of Basic Science. Tokyo. JP
  • Shono, Saori; Nippon Veterinary and Life Science University. School of Veterinary Nursing and Technology. Department of Applied Science. Tokyo. JP
  • Ishioka, Katsumi; Nippon Veterinary and Life Science University. School of Veterinary Nursing and Technology. Department of Veterinary Nursing. Tokyo. JP
  • Tamura, Tomoyoshi; Keio University. School of Medicine. Department of Emergency and Critical Care Medicine. Tokyo. JP
  • Katsumata, Yoshinori; Keio University. School of Medicine. Department of Cardiology. Tokyo. JP
  • Sano, Motoaki; Keio University. School of Medicine. Department of Cardiology. Tokyo. JP
  • Kobayashi, Eiji; Nippon Veterinary and Life Science University. School of Veterinary Nursing and Technology. Department of Basic Science. Tokyo. JP
  • Hakamata, Yoji; Nippon Veterinary and Life Science University. School of Veterinary Nursing and Technology. Department of Basic Science. Tokyo. JP
Acta cir. bras ; Acta cir. bras;39: e391324, 2024. tab, graf, ilus
Article in En | LILACS, VETINDEX | ID: biblio-1556671
Responsible library: BR68.1
Localization: BR68.1
ABSTRACT

Purpose:

To develop a new 4/6 infarct nephrectomy (INx) model rat mimicking moderate chronic kidney disease (CKD) and to evaluate its application.

Methods:

We modified the conventional 5/6 INx rat model to create the 4/6 INx model by ligating the renal artery branch to induce infarction of one-third of the left kidney after right kidney removal and compared biochemically and histologically both models. To demonstrate the application of the 4/6 INx model, the effects of a supplementary compound containing calcium carbonate, chitosan, palm shell activated charcoal etc., that is effective for both CKD and its complications, were compared between both models.

Results:

Impairment of renal function in the 4/6 INx group was significantly more moderate than in the 5/6 INx group (P < 0.05). The 4/6 INx group showed less histological damage in kidney than in the 5/6 INx group. The supplementary compound did not improve CKD in the 5/6 INx group, but ameliorated elevation of blood urea nitrogen in the 4/6 INx group.

Conclusions:

We developed the 4/6 INx model, which is more moderate than the conventional 5/6 INx model. This model could potentially demonstrate the effectiveness of drugs and supplements intended to prevent CKD and its progression.
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Full text: 1 Collection: 01-internacional Database: LILACS / VETINDEX Main subject: Renal Insufficiency, Chronic / Animals, Laboratory / Microsurgery / Nephrectomy Limits: Animals Language: En Journal: Acta cir. bras Journal subject: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Year: 2024 Document type: Article Affiliation country: Japan Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: LILACS / VETINDEX Main subject: Renal Insufficiency, Chronic / Animals, Laboratory / Microsurgery / Nephrectomy Limits: Animals Language: En Journal: Acta cir. bras Journal subject: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Year: 2024 Document type: Article Affiliation country: Japan Country of publication: Brazil