Biocellulose-based hydrogel dressing as a strategy for the management of chronic arterial wounds
Acta cir. bras
; Acta cir. bras;39: e392924, 2024. tab, graf, ilus
Article
in En
| LILACS, VETINDEX
| ID: biblio-1563648
Responsible library:
BR68.1
Localization: BR68.1
ABSTRACT
Purpose:
To evaluate using a biocellulose-based hydrogel as an adjuvant in the healing process of arterial ulcers.Methods:
A prospective single group quasi-experimental study was carried out with chronic lower limb arterial ulcer patients. These patients received biocellulose-based hydrogel dressings and outpatient guidance on dressing and periodic reassessments. The primary outcomes were the ulcer-healing rate and product safety, which were assessed by ulcer area measured in photographic records of pre-treatment and posttreatment after 7, 30, and 60 days. Secondary outcomes were related to clinical assessment by the quality-of-life scores (SF-36 and EQ-5D) and pain, evaluated by the visual analogue scale (VAS).Results:
Seventeen participants were included, and one of them was excluded. Six patients (37%) had complete wound healing, and all patients had a significant reduction in the ulcer area during follow-up (233.6mm2 versus 2.7mm2) and reduction on the score PUSH 3.0 (p < 0.0001). The analysis of the SF-36 and EQ-5D questionnaires showed a statistically significant improvement in almost all parameters analyzed and with a reduction of pain assessed by the VAS.Conclusions:
The biocellulose-based hydrogel was safe and showed a good perspective to promoting the necessary conditions to facilitate partial or complete healing of chronic arterial ulcers within a 60-day follow-up. Quality of life and pain were positively affected by the treatment.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
/
VETINDEX
Main subject:
Wound Healing
/
Wounds and Injuries
/
Hydrogels
/
Atherosclerosis
/
Peripheral Arterial Disease
Language:
En
Journal:
Acta cir. bras
Journal subject:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2024
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil