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CAR-T therapy for gastrointestinal cancers: current status, challenges, and future directions
Li, Weidong; Huang, Yueming; Zhou, Xinhao; Cheng, Bohao; Wang, Haitao; Wang, Yao.
Affiliation
  • Li, Weidong; Zhongshan City Peoples Hospital. Department of Gastrointestinal Surgery. Zhongshan. CN
  • Huang, Yueming; Zhongshan City Peoples Hospital. Department of Gastrointestinal Surgery. Zhongshan. CN
  • Zhou, Xinhao; Zhongshan City Peoples Hospital. Department of Gastrointestinal Surgery. Zhongshan. CN
  • Cheng, Bohao; Zhongshan City Peoples Hospital. Department of Gastrointestinal Surgery. Zhongshan. CN
  • Wang, Haitao; Zhongshan City Peoples Hospital. Department of Gastrointestinal Surgery. Zhongshan. CN
  • Wang, Yao; Zhongshan City Peoples Hospital. Department of Gastrointestinal Surgery. Zhongshan. CN
Braz. j. med. biol. res ; 57: e13640, fev.2024. tab, graf
Article in En | LILACS-Express | LILACS | ID: biblio-1574229
Responsible library: BR1.1
ABSTRACT
Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary immunotherapeutic strategy that has shown efficacy in hematological malignancies. However, its application in solid tumors, particularly gastrointestinal cancers, faces significant challenges. These include the selection of target antigens, the complexity of the tumor microenvironment, and safety and toxicity concerns. This review provides a current overview of CAR-T therapy in various gastrointestinal cancers, such as esophageal, gastric, colorectal, pancreatic, and liver cancers. It discusses the limitations and future directions of CAR-T therapy in this context. This review highlights innovative strategies, including novel target antigens, multispecific CAR-T cells, armored CAR-T cells, and the development of universal CAR-T cells. These insights aim to inform ongoing research and foster advancements in CAR-T therapy for gastrointestinal cancers.
Key words

Full text: 1 Collection: 01-internacional Database: LILACS Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 2024 Document type: Article / Project document Affiliation country: China Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: LILACS Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 2024 Document type: Article / Project document Affiliation country: China Country of publication: Brazil