Do you know this syndrome? Werner syndrome
An. bras. dermatol
; An. bras. dermatol;92(2): 271-272, Mar.-Apr. 2017. tab, graf
Article
in En
| LILACS
| ID: biblio-838064
Responsible library:
BR1.1
ABSTRACT
Abstract Werner syndrome is a rare autosomal recessive disorder, caused by mutations in the WRN gene. Clinical findings include senile appearance, short stature, grey hair, alopecia, bird-like face, scleroderma-like skin changes, skin ulcers, voice abnormalities, cataracts, osteoporosis, type 2 diabetes mellitus, ischemic heart disease and hypogonadism. The syndrome begins to become apparent in adolescence but it is usually diagnosed in the third or fourth decade of life. Since the patients usually die by the age of 40-50 years related to malignant neoplasms or atherosclerotic complications, they should be closely followed and treated for complications
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Werner Syndrome
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
An. bras. dermatol
Journal subject:
DERMATOLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Turkey
Country of publication:
Brazil