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Observational Cohort Study of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Routhu, Michaela; Safka, Vaclav; Kumar Routhu, Sunil; Fejfar, Tomas; Jirkovsky, Vaclav; Krajina, Antonin; Cermakova, Eva; Hulek, Petr; Hosak, Ladislav.
Affiliation
  • Routhu, Michaela; School of Psychiatry. GB
  • Safka, Vaclav; School of Psychiatry. GB
  • Kumar Routhu, Sunil; School of Psychiatry. GB
  • Fejfar, Tomas; School of Psychiatry. GB
  • Jirkovsky, Vaclav; School of Psychiatry. GB
  • Krajina, Antonin; School of Psychiatry. GB
  • Cermakova, Eva; School of Psychiatry. GB
  • Hulek, Petr; School of Psychiatry. GB
  • Hosak, Ladislav; School of Psychiatry. GB
Ann. hepatol ; 16(1): 140-148, Jan.-Feb. 2017. graf
Article in En | LILACS | ID: biblio-838096
Responsible library: BR1.1
ABSTRACT
Abstract Introduction and aim. Hepatic encephalopathy (HE) is a common complication of transjugular intrahepatic portosystemic shunting (TIPS). It is associated with a reduced quality of life and poor prognosis. The aim of this study was to compare two groups of patients who did and did not develop overt HE after TIPS. We looked for differences between these groups before TIPS. Material and methods. A study of 895 patients was conducted based on a retrospective analysis of clinical data. Data was analyzed using Fisher’s exact test, χ2, Mann Whitney test, unpaired t-test and logistic regression. After the initial analyses, we have looked at a regression models for the factors associated with development of HE after TIPS. Results. 257 (37.9%) patients developed HE after TIPS. Patients’ age, pre-TIPS portal venous pressure, serum creatinine, aspartate transaminase, albumin, presence of diabetes mellitus and etiology of portal hypertension were statistically significantly associated with the occurrence of HE after TIPS (p < 0.01). However, only the age, pre-TIPS portal venous pressure, serum creatinine, presence of diabetes mellitus and etiology of portal hypertension contributed to the regression model. Patients age, serum creatinine, presence of diabetes mellitus and portal vein pressure formed the model describing development of HE after TIPS for a subgroup of patients with refractory ascites. Conclusion. We have identified, using a substantial sample, several factors associated with the development of HE after TIPS. This could be helpful in further research.
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Hepatic Encephalopathy / Portasystemic Shunt, Transjugular Intrahepatic / Hypertension, Portal Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Patient_preference Limits: Adolescent / Adult / Aged / Aged80 / Humans Country/Region as subject: Europa Language: En Journal: Ann. hepatol Journal subject: GASTROENTEROLOGIA Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: Mexico

Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Hepatic Encephalopathy / Portasystemic Shunt, Transjugular Intrahepatic / Hypertension, Portal Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Patient_preference Limits: Adolescent / Adult / Aged / Aged80 / Humans Country/Region as subject: Europa Language: En Journal: Ann. hepatol Journal subject: GASTROENTEROLOGIA Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: Mexico