Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney
Biol. Res
; 50: 9, 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-838964
Responsible library:
CL1.1
ABSTRACT
BACKGROUND:
A number of dysregulated miRNAs have been identified and are proposed to have significant roles in the pathogenesis of type 2 diabetes mellitus or renal pathology. Alpinia oxyphylla has shown significant anti-inflammatory properties and play an anti-diabetes role. The objective of this study was to detect the alteration of miRNAs underlying the anti-diabetes effects of A. oxyphylla extract (AOE) in a type II diabetic animal model (C57BIKsj db-/db-).RESULTS:
Treatment with AOE for 8 weeks led to lower concentrations of blood glucose, urine albumin, and urine creatinine. 17 and 13 miRNAs were statistically identified as differentially regulated in the DB/DB and db-/db- AOE mice, respectively, compared to the untreated db-/db- mice. Of these, 7 miRNAs were identified in both comparison groups, and these 7 miRNAs were verified by quantitative real-time PCR. Functional bioinformatics showed that the putative target genes of 7 miRNAs were associated with several diabetes effects and signaling pathways.CONCLUSIONS:
These founding suggest that the potential of AOE as a medicinal anti-diabetes treatment through changes in the expressions of specific miRNAs. The results provide a useful resource for future investigation of the role of AOE-regulated miRNAs in diabetes mellitus.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Plant Extracts
/
MicroRNAs
/
Diabetes Mellitus, Type 2
/
Hypoglycemic Agents
/
Kidney
Type of study:
Evaluation study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2017
Document type:
Article
Affiliation country:
China
Institution/Affiliation country:
Hainan Medical College/CN