Evidence of genetic heterogeneity for hereditary gingival fibromatosis / Evidência da heterogenidade genética para fibromatose gengival hereditária
J. dent. res
; 79(10): 1758-64, Oct. 2000. ilus, tab
Article
in Portuguese
| BBO - Dentistry
| ID: biblio-851299
Responsible library:
BR97.1
Localization: BR97.1
ABSTRACT
Hereditary gingival fibromatosis (HGF) is the most common genetic form of gingival fibromatosis. The condition is most frequently reported to be transmitted as an autosomal-dominant trait, but autosomal-recessive inheritance has also been report. The clinical presentation of HGF is variable, both in the distribution (number of teeth involved) and in the degree (severity) of expression of HGF in different families is due to variable expression of a common gene mutation, allelic mutations, or non-allelic mutation, allelic mutations. The apparently different modes of Mendelian inheritance of HGF suggest genetic heterogeneity. A gene locus for HGF has been localized to a 37-cM genetic interval on chromosome 2p21-p22 (D2S1352, Zmax=5.10, O = 0.00) flanked by D2S1788 and D2S441. To evaluate the generality of this candidate region in another large family, segregating for an autosomal-dominant form of generalized HGF, and found no support for linkage with any of these markers. Furthermore, statistical tests of this apparent heterogeneity were highly significant. Analysis of these data provides direct evidence that at least two genetically distinct loci are responsible for autosomal-dominant hereditary gingival fibromatosis
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Collection:
National databases
Database:
BBO - Dentistry
Main subject:
Fibromatosis, Gingival
Language:
Portuguese
Journal:
J. dent. res
Year:
2000
Document type:
Article