Chemoluminescence generation and MTT dye reduction by polymorphonuclear leukocytes from periodontal disease patients / Geração de quimioluminescência e redução do corante MTT pelos leucócitos polimorfonucleares em pacientes portadores de doença periodontal
J. periodontal. res
; 29(2): 109-12, March. 1994. ilus, tab
Article
in English
| BBO - Dentistry
| ID: biblio-851384
Responsible library:
BR365.1
Localization: BR365.1
ABSTRACT
Alterations of polymorphonuclear leukocytes (PMNs) functions have been reported in patients with severe forms of some periodontal disease. In this study we evaluated the chemoluminescence generation and MTT dye reduction by human PMN in patients with juvenile periodontitis (JP), rapidly progressive periodontitis (RPP) and adult periodontitis (AP) during protein kinase C (PKC) activation or during the phagocytosis of opsonized zymosan. The results demonstrated that only PMNs of JP patients showed a decreased chemoluminescence generation and MTT dye reduction during the phagocytosis of oposonized zymosan (p<0.05). The time to reach the maximal peak during the PKC activation on the chemoluminescence reaction was evaluated and JP PMNs patients demonstrated a depressed value (7.0±0.4 min) compared with healthy volunteers (l3.8±0.5 min). The etiology and importance of such cellular alterations in the immunopathogenesis of the periodontal disease are discussed
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Collection:
National databases
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Oral Conditions and Disorders
/
Other Blood Disorders
Database:
BBO - Dentistry
Main subject:
Periodontal Diseases
/
Phagocytosis
/
Neutrophils
Language:
English
Journal:
J. periodontal. res
Year:
1994
Document type:
Article