Análise da resposta cicatricial da esponja Hemospon® implantada em tecido conjuntivo de rato / Analysis of the healing response of Hemospon® sponge implanted in rat connective tissue

RESUMO

O objetivo deste trabalho foi avaliar histologicamente resposta cicatricial e degradação de esponja colágena reabsorvível implantada subcutaneamente em ratos. Foram usados 14 Rattus norvegicus albinus, criados em sua região dorsal envelopes subdérmicos bilateralmente, sendo no lado experimental enxertada esponja Hemospon® e no controle sem enxertia. Como resultados após 1, 3, 7, 10, 12, 14 e 21 dias, observou-se à microscopia óptica no lado experimental remodelação progressiva da esponja de colágeno, que se integrou aos tecidos circunjacentes após 14 dias, e diminuição de infiltrado inflamatório, ausente em 7 dias, sugerindo biocompatibilidade microscópica. Conclui-se que o material testado apresenta resposta adequada dos tecidos moles e pode apresentar aplicabilidade clínica em seres humanos

ABSTRACT

The aim of this study was to evaluate histologically the healing response and degradation of a resorbable gelatin sponge implanted subcutaneously in rats. Fourteen Rattus norvegicus albinos were used, in wich skin pouches were created, bilaterally, on its back region. The experimental side was grafted with a gelatin sponge and the control side was sham-operated. Outcomes obtained via optical microscopy after 1, 3, 7, 10, 12, 14 and 21 days were reported. It was observed a progressive remodeling of the collagen sponge, decrease of the inflammatory infiltrate and integration of the sponge with the surrounding tissues after 14 days in the experimental side, suggesting microscopic biocompatibility. It was concluded that the tested material shows adequate soft tissue response and might possess clinical applicability in human beings