Your browser doesn't support javascript.
loading
Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury
Ribeiro Júnior, Rubens Fernando Gonçalves; Couteiro, Rodrigo Paracampo; Monteiro, Andrew Moraes; Rodrigues, Ivone Aline da Silva; Cavalcante, Lainy Carollyne da Costa; Gouveia, Eduardo Henrique Herbster; Galvão, Lucas Nascimento; Lopes, Luiz Renato Oliveira; Yasojima, Edson Yuzur; Brito, Marcus Vinicius Henriques.
Affiliation
  • Ribeiro Júnior, Rubens Fernando Gonçalves; Universidade Estadual do Para. Postgraduate Program in Surgery and Experimental Research. BR
  • Couteiro, Rodrigo Paracampo; Universidade Estadual do Para. Postgraduate Program in Surgery and Experimental Research. BR
  • Monteiro, Andrew Moraes; Universidade Estadual do Para. Postgraduate Program in Surgery and Experimental Research. BR
  • Rodrigues, Ivone Aline da Silva; Universidade Estadual do Para. Postgraduate Program in Surgery and Experimental Research. BR
  • Cavalcante, Lainy Carollyne da Costa; Universidade Estadual do Para. Postgraduate Program in Surgery and Experimental Research. BR
  • Gouveia, Eduardo Henrique Herbster; Universidade Estadual do Para. Postgraduate Program in Surgery and Experimental Research. BR
  • Galvão, Lucas Nascimento; Universidade Estadual do Para. Postgraduate Program in Surgery and Experimental Research. BR
  • Lopes, Luiz Renato Oliveira; Universidade Estadual do Para. Postgraduate Program in Surgery and Experimental Research. BR
  • Yasojima, Edson Yuzur; Universidade Estadual do Para. Postgraduate Program in Surgery and Experimental Research. BR
  • Brito, Marcus Vinicius Henriques; Universidade Estadual do Para. Postgraduate Program in Surgery and Experimental Research. BR
Acta cir. bras ; 32(11): 949-955, Nov. 2017. tab, graf
Article in English | LILACS | ID: biblio-886182
Responsible library: BR1.1
ABSTRACT
Abstract

Purpose:

To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats.

Methods:

25 male rats (Wistar) were distributed into five groups Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments.

Results:

Per+HSS group showed a lower degree of liver dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly improved liver function and reduced histological damage.

Conclusion:

Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute liver injury induced by ischemia/reperfusion.
Subject(s)

Fulltext
Add to My VHL
Print
XML
Search on Google

Full text: Available Collection: International databases Database: LILACS Main subject: Saline Solution, Hypertonic / Reperfusion Injury / Ischemic Preconditioning / Protective Agents / Liver Type of study: Risk factors Limits: Animals Language: English Journal: Acta cir. bras Journal subject: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual do Para/BR
Fulltext
Add to My VHL
Print
XML
Search on Google

Full text: Available Collection: International databases Database: LILACS Main subject: Saline Solution, Hypertonic / Reperfusion Injury / Ischemic Preconditioning / Protective Agents / Liver Type of study: Risk factors Limits: Animals Language: English Journal: Acta cir. bras Journal subject: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual do Para/BR