Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables
An. acad. bras. ciênc
; 89(1,supl): 615-633, May. 2017. graf
Article
in English
| LILACS
| ID: biblio-886649
Responsible library:
BR1.1
ABSTRACT
ABSTRACT The endothelium is fundamental for the regulation of vascular tone and structure. Under disease conditions, including the presence of cardiovascular disease risk factors, the endothelium loses its protective role and becomes a proatherosclerotic structure. In this article we searched for strategies from PUBMED and Science Direct databases using the following key words endothelium, natural bioactive compounds, polyphenols and cardiovascular diseases. The search was restricted to english language papers. Studies have identified the contribution of diet to the risk of developing cardiovascular diseases. In this context, high intakes of fruit and vegetables are associated with the decrease of cardiovascular diseases. Thus the most important fruit/vegetables and bioactive compounds to prevent endothelial diseases are berries, apples, virgin olive oil, tomatoes, soybeans, and polyphenols, carotenoids and unsaturated fatty acids, respectively. The bioactive compounds from fruit and vegetables provide endothelial protection through the following mechanisms improved eNOS/NO bioavailability, attenuates oxidative stress, inhibited NF-κB pathway and decreased cell adhesion molecules expression. In this article natural bioactive compound mechanisms of endothelium protection are thoroughly reviewed.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Vegetables
/
Endothelium, Vascular
/
Protective Agents
/
Diet, Mediterranean
/
Fruit
Type of study:
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
An. acad. bras. ciênc
Journal subject:
Science
Year:
2017
Document type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Talca/CL