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Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
Wang, YH; Ke, XM; Zhang, CH; Yang, RP.
Affiliation
  • Wang, YH; Chongqing Academy of Chinese Materia Medica. Chongqing. CN
  • Ke, XM; Chongqing Academy of Chinese Materia Medica. Chongqing. CN
  • Zhang, CH; Chongqing Academy of Chinese Materia Medica. Chongqing. CN
  • Yang, RP; Chongqing Academy of Chinese Materia Medica. Chongqing. CN
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;50(11): e6353, 2017. tab, graf
Article in En | LILACS | ID: biblio-888951
Responsible library: BR1.1
ABSTRACT
This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Adjuvants, Pharmaceutic / Curcumin / Enzyme Inhibitors / Intestinal Absorption / Intestine, Small Type of study: Evaluation_studies Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 2017 Document type: Article / Project document Affiliation country: China Country of publication: Brazil
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Adjuvants, Pharmaceutic / Curcumin / Enzyme Inhibitors / Intestinal Absorption / Intestine, Small Type of study: Evaluation_studies Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 2017 Document type: Article / Project document Affiliation country: China Country of publication: Brazil