Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms
Braz. j. med. biol. res
; 50(12): e6138, 2017. graf
Article
in English
| LILACS
| ID: biblio-888969
Responsible library:
BR1.1
ABSTRACT
The aim of this study was to investigate the mechanism of propranolol on the regression of hemangiomas. Propranolol-treated hemangioma tissues were collected and the expression of hypoxia inducible factor-1α (HIF-1α) was examined. We also established HIF-1α overexpression and knockdown hemangioma cells, and determined the effects of HIF-1α on the hemangioma cells proliferation, apoptosis, migration and tube formation. Significantly increased HIF-1α level was found in the hemangioma tissues compared to that in normal vascular tissues, whereas propranolol treatment decreased the HIF-1α level in hemangioma tissues in a time- and dose-dependent manner. Moreover, propranolol treatment significantly decreased cell proliferation, migration and tube formation as well as promoted cell apoptosis in HIF-1α overexpression and knockdown hemangioma cells. Propranolol suppressed the cells proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms. HIF-1α could serve as a novel target in the treatment of hemangiomas.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Propranolol
/
Vasodilator Agents
/
Cell Movement
/
Cell Proliferation
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Hemangioma
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2017
Document type:
Article
/
Project document
Affiliation country:
China
Institution/Affiliation country:
Shandong University/CN