Second hand tobacco smoke adversely affects the bone of immature rats
Clinics
; 72(12): 785-789, Dec. 2017. graf
Article
in English
| LILACS
| ID: biblio-890700
Responsible library:
BR1.1
ABSTRACT
OBJECTIVES:
To evaluate the influence of secondhand cigarette smoke exposure on longitudinal growth of the tibia of growing rats and some parameters of bone quality.METHODS:
Forty female rats were randomly divided into four groups control rats were sham exposed; 30 days rats were exposed to tobacco smoke for 30 days; 45 days rats were exposed to tobacco smoke for 45 days; and 60 days rats were exposed to tobacco smoke for 60 days. Blood samples were collected to evaluate the levels of cotinine and alkaline phosphatase. Both tibias were dissected and weighed; the lengths were measured, and the bones were then stored in a freezer for analysis of bone mineral content and mechanical resistance (maximal load and stiffness).RESULTS:
Exposure of rats to tobacco smoke significantly compromised bone health, suggesting that the harmful effects may be time dependent. Harmful effects on bone growth were detected and were more pronounced at 60-day follow-ups with a 41.8% reduction in alkaline phosphatase levels (p<0.01) and a decrease of 11.25% in tibia length (p<0.001). Furthermore, a 41.5% decrease in bone mineral density was observed (p<0.001), leading to a 42.8% reduction in maximum strength (p<0.001) and a 56.7% reduction in stiffness (p<0.001).CONCLUSION:
Second hand cigarette smoke exposure in rats affected bones that were weaker, deforming them and making them osteopenic. Additionally, the long bone was shorter, suggesting interference with growth. Such events seem to be related to time of exposure.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.9: Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
Database:
LILACS
Main subject:
Tibia
/
Tobacco Smoke Pollution
/
Bone Density
/
Inhalation Exposure
/
Cotinine
Limits:
Animals
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2017
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Triângulo Mineiro/BR