Tissue-based molecular markers in upper tract urothelial carcinoma and their prognostic implications
Int. braz. j. urol
; 44(1): 22-37, Jan.-Feb. 2018. tab
Article
in English
| LILACS
| ID: biblio-892953
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Upper tract urothelial carcinoma (UTUC) is a rare and aggressive disease that is associated with high rates of recurrence and death. Radical nephroureterectomy (RNU) with excision of the bladder cuff is considered the standard of care for high-risk UTUC, whereas kidney-sparing techniques can be indicated for select patients with low-risk disease. There is a significant lack of clinical and pathological prognostic factors for stratifying patients with regard to making treatment decisions. Incorporation of tissue-based molecular markers into prognostic tools could help accurately stratify patients for clinical decision-making in this heterogeneous disease. Although the number of studies on tissue-based markers in UTUC has risen dramatically in the past several years—many of which are based on single centers and small cohorts, with a low level of evidence—many discrepancies remain between their results. Nevertheless, certain biomarkers are promising tools, necessitating prospective multi-institution studies to validate their function.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Biomarkers, Tumor
/
Urologic Neoplasms
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2018
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
AC Camargo Cancer Center/BR