Brazilian guidelines for the clinical management of paracoccidioidomycosis
Rev. Soc. Bras. Med. Trop
; 50(5): 715-740, Sept.-Oct. 2017. tab, graf
Article
in English
| Sec. Est. Saúde SP, SESSP-IIERPROD, Sec. Est. Saúde SP
| ID: biblio-897015
Responsible library:
BR31.1
Localization: BR31.1; 2017_P-021
ABSTRACT
Abstract Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis ( P. brasiliensis ) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii ( P. lutzii ), has been reported in Rondônia, where the disease has reached epidemic levels, and in the Central West and Pará. Accurate diagnoses and availability of antigens that are reactive with the patients' sera remain significant challenges. Therefore, the present guidelines aims to update the first Brazilian consensus on paracoccidioidomycosis by providing evidence-based recommendations for bedside patient management. This consensus summarizes etiological, ecoepidemiological, molecular epidemiological, and immunopathological data, with emphasis on clinical, microbiological, and serological diagnosis and management of clinical forms and sequelae, as well as in patients with comorbidities and immunosuppression. The consensus also includes discussion of outpatient treatments, severe disease forms, disease prevalence among special populations and resource-poor settings, a brief review of prevention and control measures, current challenges and recommendations.
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
SDG3 - Target 3.3 End transmission of communicable diseases
Health problem:
Paracoccidioidomycosis
Database:
Sec. Est. Saúde SP
/
SESSP-IIERPROD
Main subject:
Paracoccidioidomycosis
Type of study:
Practice guideline
/
Qualitative research
/
Risk factors
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Year:
2017
Document type:
Article
Institution/Affiliation country:
Centro de Medicina Tropical de Rondônia/BR
/
Fundação Oswaldo Cruz/BR
/
Northern Arizona University/US
/
Secretaria de Estado da Saúde. São Paulo/BR
/
Universidade Estadual Paulista/BR
/
Universidade Estadual de Campinas/BR
/
Universidade Federal de Mato Grosso/BR
/
Universidade Federal de São Paulo/BR
/
Universidade Federal de Uberlândia/BR
/
Universidade Federal do Paraná/BR