GC-MS based metabolite profiling and angiotensin I-converting enzyme inhibitory property of black tea extracts
Rev. bras. farmacogn
; 27(5): 580-586, Sept.-Oct. 2017. tab, graf
Article
in En
| LILACS
| ID: biblio-898706
Responsible library:
BR8.1
ABSTRACT
Abstract Angiotensin I-converting enzyme inhibitors are used as therapeutic agents for the treatment of hypertension. Regular consumption of black tea (Camellia sinensis (L.) Kuntze, Theaceae) has been reported to lower blood pressure. The aims of the present work were to compare chemical composition and angiotensin I-converting enzyme inhibitory properties of infusion and decoction of four samples of black tea. GC/MS based metabolomics approach helped in identification of fifty-one metabolites including ten organic acids, one inorganic acid, sixteen amino acids, two sugars, five sugar alcohols, fifteen phenols and flavonoids, two fatty acids from infusions and decoctions of four black tea samples. Partial least squares discriminant analysis and orthogonal partial least squares discriminant analysis models showed good classification among the two groups, diffusion and infusion, based on metabolites. Both infusion and decoction inhibited the enzyme. However, the activity differed with samples. Multivariate analysis also segregated extracts on the basis of activity. Thearubigin, theaflavin, catechin inhibited the enzyme. Epicatechin, epigallocatechin gallate, gallic acid, caffeine showed lower activity.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Language:
En
Journal:
Rev. bras. farmacogn
Journal subject:
FARMACIA
Year:
2017
Document type:
Article
Affiliation country:
India
Country of publication:
Brazil