Changes in the Immuno-Expression of Galectins -1, -3 and -7 in Relation to the Biological Behavior of Lip Squamous Cell Carcinoma
Pesqui. bras. odontopediatria clín. integr
; 17(1): e2759, 13/01/2017. ilus, tab
Article
in English
| LILACS, BBO - Dentistry
| ID: biblio-914243
Responsible library:
BR1822.9
ABSTRACT
Objective:
To evaluate the expression through immunohistochemistry of galectins -1, - 3 and -7 in cases of lip squamous cell carcinoma (SCC) in association with clinical data and morphological parameters proposed by Bryne (1998). Material andMethods:
Thirty paraffin-embedded SCC cases were submitted to histological sections. Two independent pathologists performed the analysis of galectins -1, -3 and -7 through light microscopy evaluating the presence or absence of marking and intensity. The expressions of these proteins were submitted to statistical analysis (chi-square test, Fisher's exact test and Binomial test for the comparison of proportions).Results:
Positive expression of galectins -1 and -3 was observed in 93.3% and 43.3% of cases, respectively. However, there was no statistically significant association between these proteins and the clinical variables used. Galectin-7 immuno-expression was present in all cases evaluated and showed statistical significance between marked cell type (parenchyma cells) and regional metastasis and between marked cell type (parenchyma cells) and histological gradation.Conclusion:
Changes in the galectins -1, -3 and -7 expression suggest the participation of these proteins in the regulation of cellular functions and that the immuno-expression of these proteins can act as a marker of the biological behavior of lip squamous cell carcinoma.
Full text:
Available
Collection:
International databases
Database:
BBO - Dentistry
/
LILACS
Main subject:
Mouth Neoplasms
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Galectins
Type of study:
Diagnostic study
/
Evaluation study
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Pesqui. bras. odontopediatria clín. integr
Journal subject:
Dentistry
Year:
2017
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Paraiba/BR
/
Federal University of Rio Grande do Norte/BR
/
State University of Paraiba/BR