P-glycoprotein expression, tumor weight, age, and relapse in patients with stage I and II favorable-histology Wilms' tumor
Pediatr Hematol Oncol
; 28(3): 194-202, 2011.
Article
in English
| Coleciona SUS
| ID: biblio-945461
Responsible library:
BR440.1
Localization: BR440.1
ABSTRACT
Fifteen percent of patients with Wilms' tumor (WT) experience relapse. It has been suggested that weight and age may affect the chances of relapse. Few studies have investigated the role, if any, between P-glycoprotein (P-gp) and relapse. The authors assessed the prognostic value of tumor weight and age at diagnosis and asked whether some other potential biological markers, specifically P-gp protein expression, had a prognostic value in favorable-histology WT. No association between age and relapse could be found. Patients with tumor weight ¡Ý550 g were 6 times more likely to relapse, whereas P-gp expression was positive in 18/40 (45%) of the patients, of which 10/12 (83.3%) relapsed and 8/28 (28.6%) did not. Further studies are necessary to elucidate whether or not P-gp is related to relapse in patients with histologically favorable Wilms' tumor. If confirmed, the protein may be used in the future as a target for new drugs and treatments for this group of patients
Full text:
Available
Collection:
National databases
/
Brazil
Database:
Coleciona SUS
Main subject:
Wilms Tumor
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
Tumor Burden
/
Kidney Neoplasms
/
Neoplasm Recurrence, Local
/
Neoplasm Staging
Type of study:
Prognostic study
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
Language:
English
Journal:
Pediatr Hematol Oncol
Year:
2011
Document type:
Article