Molecular epidemiology of dengue virus serotypes 2 and 3 isolated in Brazil from 1991 to 2008 / Epidemiologia molecular dos sorotipos 2 e 3 do vírus dengue, isolados no Brasil de 1991 a 2008
Rev. Pan-Amazônica Saúde (Online)
; 1(3): 25-34, 2010.
Article
in Spanish
| Coleciona SUS
| ID: biblio-945936
Responsible library:
BR275.1
Localization: BR275.1
ABSTRACT
The dengue virus (DENV1-4) causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) in tropical and subtropical areas. The aim of this study was to evaluate the circulating genotypes of DENV. This was accomplished by sequencing the PrM and E genes of Brazilian isolates of DENV2 and DENV3 that were obtained between 1991 and 2008 from various geographic regions. Phylogenetic analyses of DENV2 demonstrated that the genotype III (Southeast Asian/American), in spite of several nucleotide and amino acid changes, was the only one that circulated over the past 19 years. Since its introduction in 2000, the DENV3 isolates that have been analyzed have all grouped intogenotype III (Indian subcontinent) and there has been no evidence of DENV3 belonging to other genotypes in this study.
RESUMO
O vírus dengue (DENV1-4) causa a dengue clássica e a febre hemorrágica da dengue / síndrome de choque da dengue (FHD/SCD) em regiões tropicais e subtropicais. O objetivo deste estudo foi avaliar os genótipos circulantes de DENV2 e DENV3 obtidos em distintas regiões geográficas no período de 1991 a 2008. As análises filogenéticas de DENV2 demonstraram que o genótipo III (Sudeste da Ásia/América), apesar das diversas alterações nucleotídicas e de aminoácidos, foi o único a circular durante os últimos 19 anos. Desde a sua introdução no estudo, em 2000, todas as amostras isoladas de DENV3 analisadas foram agrupadas no genótipo III (subcontinente indiano). Não foram encontradas evidências de que o DENV3 pertença a outros genótipos investigados.
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
Neglected Diseases
Health problem:
Dengue
/
Neglected Diseases
Database:
Coleciona SUS
Main subject:
Severe Dengue
/
Dengue Virus
/
Flavivirus
Type of study:
Screening study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
Spanish
Journal:
Rev. Pan-Amazônica Saúde (Online)
Year:
2010
Document type:
Article
Institution/Affiliation country:
Fundação de Medicina Tropical do Tocantins/BR
/
Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos/BR
/
Ministério da Saúde/BR