IMPORTANCIA FISIOPATOLÓGICA SISTÉMICA DE LA MICROBIOTA INTESTINAL ASOCIADA AL SISTEMA INMUNE DE MUCOSAS / Systemic physiopathologic significance of the intestinal microbiota associated to mucosal immune system
Arch. alerg. inmunol. clin
; 45(2): 71-78, 2014. ilus
Article
in Spanish
| LILACS
| ID: biblio-947409
Responsible library:
AR144.1
RESUMEN
La microbiota intestinal representa una unidad biológica dinámica que ejerce su influencia sistémica no solamente a nivel gastrointestinal sino también metabólico-endocrino, inmunológico, neurológico. Está implicada en la regulación de procesos fisiopatológicos que se pueden manifestar en disbiosis y enfermedad inflamatoria, con impacto intestinal, metabólico, alérgico, del sistema nervioso central, y en autoinmunidad. Los conocimientos de la genética microbiana, la interacción con el sistema inmune de mucosas y con el ecosistema entériconutricional de cada individuo permiten establecer proyecciones muy interesantes para modular preventiva y terapéuticamente diversas enfermedades.(AU)
ABSTRACT
The intestinal microbiota is a dynamic biological unit with systemic influences not only gastrointestinal but also at metabolic-endocrine, and at immunologic and neurological levels. The microbiota is involved in pathophysiological processes regulation that could manifest as dysbiosis and inflammatory disease with gastrointestinal impact, also metabolic and/or allergic manifestations, in central nervous system, and autoimmunity. The knowledge of microbial genetics, the interaction with the mucosal immune system, and the enteric-nutritional ecosystem of each individual, will allow to develop very interesting designs to prevent and therapeutically modulate various diseases(AU)
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Zoonoses
Database:
LILACS
Main subject:
Microbiota
/
Gastrointestinal Microbiome
/
Immune System
Type of study:
Risk factors
Limits:
Adult
/
Child
/
Humans
Language:
Spanish
Journal:
Arch. alerg. inmunol. clin
Journal subject:
Allergy and Immunology
Year:
2014
Document type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Hospital Juan A.Fernández/AR