CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast
Biol. Res
; 47: 1-5, 2014. ilus, tab
Article
in En
| LILACS
| ID: biblio-950739
Responsible library:
CL1.1
ABSTRACT
BACKGROUND:
Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma.RESULTS:
Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2.CONCLUSIONS:
These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Breast Neoplasms
/
Biomarkers, Tumor
/
Trans-Activators
/
Adenocarcinoma, Mucinous
/
Homeodomain Proteins
/
Beta Catenin
/
Mucin-2
/
Intestinal Mucosa
Type of study:
Observational_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
Language:
En
Journal:
Biol. Res
Journal subject:
BIOLOGIA
Year:
2014
Document type:
Article
Affiliation country:
Mexico
Country of publication:
Chile