Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
Biol. Res
; 47: 1-8, 2014. graf
Article
in English
| LILACS
| ID: biblio-950770
Responsible library:
CL1.1
ABSTRACT
BACKGROUND:
Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption, nitric oxide (NO) synthesis, ATPase activity and lipid oxidation in mitochondria isolated from liver and kidneys of diabetic db/db mice.RESULTS:
Hyperglycaemia increased oxygen consumption and decreased NO synthesis in liver mitochondria isolated from diabetic mice relative to the control mice. In kidney mitochondria, hyperglycaemia increased state 3 oxygen consumption and thiobarbituric acid-reactive substances (TBARS) levels in diabetic mice relative to control mice. Interestingly, treating db/db mice with curcumin improved or restored these parameters to normal levels; also curcumin increased liver mitochondrial ATPase activity in db/db mice relative to untreated db/db mice.CONCLUSIONS:
These findings suggest that hyperglycaemia modifies oxygen consumption rate, NO synthesis and increases TBARS levels in mitochondria from the liver and kidneys of diabetic mice, whereas curcumin may have a protective role against these alterations.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Lipid Peroxidation
/
Curcumin
/
Diabetes Mellitus, Type 2
/
Kidney
/
Liver
/
Mitochondria
Type of study:
Etiology study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2014
Document type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Universidad Michoacana de San Nicolás de Hidalgo/MX
/
Universidad de Guanajuato/MX