Prevalence of Guillain-Barré syndrome among Zika virus infected cases: a systematic review and meta-analysis
Braz. j. infect. dis
; 22(2): 137-141, Mar.-Apr. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-951630
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Zika virus (ZIKV) is an emergent flavivirus transmitted mainly through Aedes spp. mosquitoes that is posing challenge to healthcare services in countries experiencing an outbreak. Usually ZIKV infection is mild, but in some cases it has been reported to progress into neurological diseases such as microcephaly in infants and Guillain-Barré syndrome (GBS) in adults. GBS is a debilitating autoimmune disorder that affects peripheral nerves. Since ZIKV caused massive outbreaks in South America in the past few years, we aimed to systematically review the literature and perform a meta-analysis to estimate the prevalence of GBS among ZIKV-infected individuals. We searched PubMed and Cochrane databases and selected three studies for a meta-analysis. We estimated the prevalence of ZIKV-associated GBS to be 1.23% (95% CI = 1.17-1.29%). Limitations include paucity of data regarding previous flavivirus infections and ZIKV-infection confirmation issues. Our estimate seems to be low, but cannot be ignored, since ZIKV outbreaks affects an overwhelming number of individuals and GBS is a life-threatening debilitating condition, especially in pregnant women. ZIKV infection cases must be closely followed to assure prompt care to reduce the impact of GBS associated-sequelae on the quality of life of those affected.
Full text:
Available
Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 8: Outbreaks, emergencies and disasters
/
Target 3.3: End transmission of communicable diseases
Database:
LILACS
Main subject:
Disease Outbreaks
/
Guillain-Barre Syndrome
/
Zika Virus
/
Zika Virus Infection
Type of study:
Prevalence study
/
Risk factors
/
Systematic review
Aspects:
Patient-preference
Limits:
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Central America
/
South America
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2018
Document type:
Article
Affiliation country:
Brazil
/
Italy
/
United kingdom
Institution/Affiliation country:
King's College London/GB
/
Scientific Institute for Research, Hospitalization and Care/IT
/
Universidade Federal de Pernambuco/BR