Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
Braz. J. Pharm. Sci. (Online)
; 54(2): e17484, 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-951942
Responsible library:
BR1.1
ABSTRACT
Abstract The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients.
Full text:
Available
Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 9: Noncommunicable diseases and mental health
/
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
LILACS
Main subject:
Diabetes Mellitus, Type 2
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Diabetic Retinopathy
Type of study:
Observational study
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Prognostic study
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Risk factors
Limits:
Adult
/
Aged
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Aged, 80 and over
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Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2018
Document type:
Article
/
Project document
Affiliation country:
Malaysia
Institution/Affiliation country:
UiTM/MY
/
University of Malaya/MY