Vascular and ventilatory mechanical responses in three different stages of pulmonary development in the rabbit model of congenital diaphragmatic hernia
Acta cir. bras
; 33(10): 879-888, Oct. 2018. graf
Article
in English
| LILACS
| ID: biblio-973464
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the vascular ventilatory response in different stages of lung development and to compare them to the neonates with congenital diaphragmatic hernia (CDH) in a rabbit model.Methods:
New Zealand rabbits were divided into 8 groups (n=5) E25, E27, E30, and CDH. All groups were ventilated on a FlexiVent (Scireq, Montreal, QC, Canada), compounding the other 4 groups. The CDH surgery was performed at E25 and the harvest at E30. Dynamic compliance (CRS), dynamic elastance (ERS) and dynamic resistance (RRS) were measured every 4 min/24 min. Median wall thickness (MWT) and airspace were measured. ANOVA Bonferroni tests were used to perform statistical analysis. Significance was considered when p<0.05.Results:
CRS was higher in E30 compared to all other groups (p<0.05). CRS and RRS of CDH and E27 were similar and were higher in E25 (p<0.05). MWT was decreased according to the gestational age, was increased in E27V and E30V (p<0.05) and decreased in CDHV (p<0.05), airspace was decreased in E25 and increased in all ventilated groups (p<0.05).Conclusions:
The ventilation response of congenital diaphragmatic hernia is like the pseudoglandular stage of the lung development. These findings add information about the physiology of pulmonary ventilation in CDH.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Respiratory Mechanics
/
Hernias, Diaphragmatic, Congenital
/
Lung
Type of study:
Etiology study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
USP/BR
/
Universidade de São Paulo/BR