Association of Interleukin-10 -1082A>G (rs1800896) Polymorphism with Predisposition to Breast Cancer: a Meta-Analysis based on 17 Case-Control Studies
Rev. Assoc. Med. Bras. (1992, Impr.)
; 64(8): 756-764, Aug. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-976846
Responsible library:
BR1.1
ABSTRACT
SUMMARY INTRODUCTION The association between the between IL-10 -1082A>G (rs1800896) polymorphism and breast cancer has been evaluated by several number case-control studies. However, these studies might be underpowered to reveal the true association. OBJECTIVE We have performed a comprehensive meta-analysis to investigate the association IL-10 -1082A>G polymorphism and breast cancer. MATERIALS AND METHODS A systematic literature search was conducted using PubMed, Google Scholar, and Web of Science up to September 20, 2017. Data was analysed with CMA software to identify the strength of the association by pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs). RESULTS A total of 17 case-control studies involving 3275 cases and 3416 controls obtained from database searches were examined. Overall, there was no significant association between IL-10 -1082A>G polymorphism and breast cancer risk under all genetic models. No significant publication bias was found for the five genetic models (G vs. A OR = 1.184, 95% CI = 0.895-1.180, p= 0.230; GG vs. AA OR = 1.430, 95% CI = 0.927-2.204, p= 0.106; GA vs. AA OR = 0.966, 95% CI = 0.765-1.221, p= 0.774; GG+GA vs. AA OR = 0.957, 95% CI = 0.697-1.314, p= 0.786; and GG vs. GA+AA OR = 1.221, 95% CI = 0.981-1.518, p= 0.073). Moreover, there was no significant association between the IL-10 -1082A>G polymorphism and breast cancer risk by ethnicity. CONCLUSION Our findings indicated that IL-10 -1082A>G (rs1800896) polymorphism might not be a risk factor for the development of breast cancer.
RESUMO
RESUMO
A associação entre o polimorfismo IL-10 -1082A> L (rs1800896) e o câncer da mama foi avaliada por vários estudos de casos-controle. No entanto, esses estudos podem ser insuficientes para revelar a verdadeira associação. Efetuamos uma meta-análise abrangente para investigar a associação entre o polimorfismo IL-10 -1082A> G e câncer de mama. Uma busca sistemática da literatura foi conduzida usando PubMed, Google Scholar e Web of Science até 20 de setembro de 2017. Os dados foram analisados com o software CMA para identificar a força da associação por proporções compartilhadas (RUP) com correspondentes intervalos de confiança de 95% (ICs). Um total de 17 estudos de casos-controle envolvendo 3.275 casos e 3.416 controles obtidos a partir de pesquisas de banco de dados foram examinados. Em geral, não existe uma associação significativa entre o polimorfismo IL-10 -1082A> G e o risco de câncer de mama, sob todos os modelos genéticos. Não foi encontrado nenhum viés de publicação significativo para os cinco modelos genéticos (G vs. A: OR = 1,184, IC 95% = 0,895-1,180, p=0,230; Breast neoplasms; GA vs. AA: OR = 0,966, IC 95% = 0,765-1,221, p=0,774; GG + GA vs. AA: OR = 0,957, IC 95% = 0,697-1,314, p=0,786 e GG vs. GA + AA: OR = 1,221, IC 95% = 0,981-1,518, p=0,073). Além disso, não houve associação significativa entre o polimorfismo IL-10 -1082A> L e o risco de câncer de mama por etnia. Nossos resultados indicam que o polimorfismo IL-10 -1082A> G (rs1800896) não pode ser um fator de risco para o desenvolvimento de câncer de mama; GG vs. AA: OR = 1,430, IC 95% = 0,927-2,204, p=0,106; Interleucina-10; Interleukin-10; Meta-analysis; Metanálise; Neoplasias da mama; Polimorfismo genético; Polymorphism, genetic
Full text:
Available
Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 9: Noncommunicable diseases and mental health
/
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
LILACS
Main subject:
Polymorphism, Genetic
/
Breast Neoplasms
/
Interleukin-10
/
Genetic Predisposition to Disease
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Systematic review
Limits:
Female
/
Humans
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicine
Year:
2018
Document type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Arak University of Medical Sciences/IR
/
Arak university of Medical Sciences/IR
/
Kashan University of Medical Sciences/IR
/
Shahid Sadoughi University of Medical Sciences/IR
