What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice?
São Paulo med. j
; 136(5): 472-478, Sept.-Oct. 2018. tab
Article
in English
| LILACS
| ID: biblio-979377
Responsible library:
BR1.1
ABSTRACT
ABSTRACT BACKGROUND:
The therapeutic effects of cannabinoid compounds have been the center of many investigations. This study provides a synthesis on all Cochrane systematic reviews (SRs) that assessed the use of cannabinoids as a therapeutic approach. DESIGN ANDSETTING:
Review of SRs, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP).METHODS:
A broad search was conducted in the Cochrane Database of Systematic Reviews to retrieve any Cochrane SRs that assessed the efficacy and safety of cannabinoids as a therapeutic approach. The results and key characteristics of all reviews included were summarized and discussed.RESULTS:
Eight SRs were included. They assessed the use of cannabinoids for the following types of conditions neurological (two SRs), psychiatric (two SRs), rheumatological (one SR), infectious (one SR) and oncological (two SRs). There was moderate-quality evidence showing that the use of cannabinoids reduced nausea and vomiting among adults, compared with placebo. Additionally, there was moderate-quality evidence showing that there was no difference between cannabinoids and prochlorperazine regarding the number of participants who reported vomiting, in this same population.CONCLUSIONS:
This review identified eight Cochrane systematic reviews that provided evidence of unknown to moderate quality regarding the use of cannabinoids as a therapeutic intervention. Further studies are still imperative for solid conclusions to be reached regarding practical recommendations.
Full text:
Available
Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
/
SDG3 -Target 3.5 Prevention and treatment of consumption of psychoactive substances
Health problem:
Goal 7: Evidence and knowledge in health
/
Target 3.3: End transmission of communicable diseases
/
Cannabis Related Disorders
/
Cocaine and Other Stimulant-Related Disorders
Database:
LILACS
Main subject:
Cannabinoids
/
Systematic Reviews as Topic
Type of study:
Controlled clinical trial
/
Practice guideline
/
Prognostic study
/
Systematic review
Limits:
Humans
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
2018
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de São Paulo/BR
/
Universidade Metropolitana de Santos/BR