Primary endometrial large cell neuroendocrine carcinoma with melanocytic differentiation
Autops. Case Rep
; 8(4): e2018041, Oct.-Dec. 2018. ilus
Article
in English
| LILACS
| ID: biblio-986588
Responsible library:
BR26.7
ABSTRACT
High-grade endometrial carcinomas are aggressive neoplasms of difficult histological classification. Neuroendocrine differentiation in endometrial carcinomas is rare. This is the report of an endometrial large cell neuroendocrine carcinoma with foci of melanocytic differentiation in a 75-year-old woman with abnormal post-menopausal uterine bleeding for 2 years. Two initial biopsies were inconclusive. Histopathological examination of the uterus revealed large cell neuroendocrine carcinoma associated with endometrioid carcinoma and foci of melanocytic differentiation, pT3a (FIGO IIIA). There were metastases in the rectum serosa and lungs. After 8 months of diagnosis and surgical treatment, the patient is on chemotherapy and radiotherapy. We highlight the morphological characteristics and criteria that allow the definitive anatomopathological diagnosis, including immunohistochemical markers used to identify the cell types present in this unprecedented association.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Endometrial Neoplasms
/
Carcinoma, Neuroendocrine
Type of study:
Prognostic study
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
Autops. Case Rep
Journal subject:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Year:
2018
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Triângulo Mineiro/BR