Changes in crossover distribution along a quadrivalent in aman carrier of a reciprocal translocation t(11; 14)
Biocell
; 29(2): 195-203, ago. 2005. ilus, tab, graf
Article
in English
| BINACIS
| ID: bin-111
Responsible library:
AR40.1
ABSTRACT
A testicu1ar biopsy from an infertile man carrying a heterozygous chromosome translocation t(ll; 14) was studied with synaptonemal complex analysis and immunolocalization of the protein MLH 1 for crossover detection. A full blockage of spermatogenesis at the spermatocyte stage was related to the presence of the translocation quadrivalents at pachytene. Only 2% of the quadrivalents showed full synapsis. Most of the spermatocytes showed asynaptic free ends that frequently mingled with the XY pair. The average number of crossovers per cell was diminished from a mean of 52.7 in controls to a mean of 48 in the patient. The difference between the number of crossovers in the quadrivalent and the normal bivalents was highly significant. The distribution of crossovers over the segment of the quadrivalent corresponding to bivalent #14 was also very different from that ofthe control. It is concluded that in this translocation, the pattern of crossovers is changed, mainly due to a synaptic hindrance in the quadrivalent, and that the spermatogenesis arrest is mainly due to the quadrivalents that interact with the XY pair
Search on Google
Collection:
National databases
/
Argentina
Database:
BINACIS
Main subject:
Spermatogenesis
/
Chromosomes, Human, Pair 11
/
Chromosomes, Human, Pair 14
/
Infertility, Male
/
Meiosis
Type of study:
Diagnostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Biocell
Year:
2005
Document type:
Article
Institution/Affiliation country:
Universidad Nacional de Buenos Aires/Argentina