Ocular lesions and experimental choline deficiency
Medicina (B.Aires)
; 66(5): 415-420, 2006. tab, ilus
Article
in English
| BINACIS
| ID: bin-123198
Responsible library:
BR1.1
ABSTRACT
Previous studies have shown ocular haemorrhages in choline-deficient rats. The aim of this paper is to study further the relationship between ocular and renal lesions and biochemical alterations in rats fed a choline-deficient diet. Fifty one weanling male Wistar rats, were divided into two groups. Thirty one ofthem were fed a choline-deficient diet and the rest was fed a choline- supplemented diet ad libitum. Animalsfrom both groups were killed between the fifth and the eighth day. Urea, creatinine and homocysteine concentrations in blood were determined. Eyes were used for light microscopy study; high resolution lightmicroscopy and the study of the retina as ¶rétine a plat÷. Kidneys were studied by light microscopy. Cholinesupplementedrats did not show ocular or renal lesion. Choline-deficient rats that showed renal lesions, tubular or cortical necrosis, did not always have ocular changes. There were no ocular changes in the only cholinedeficient rat without renal lesion. The ocular changes consisted mainly in haemorrhage in both cameras andciliary and vitreous bodies. Correlations between ocular and renal lesion (r=0.72, p<0.0001, CI 95% 0.48-0.86); ocular lesion and creatinine (r=0.86, p<0.0001, CI 95% 0.72-0.93) and ocular lesion and urea (r=0.70, p<0.0001, CI 95% 0.44-0.85) were positive. Choline-deficiency induces ocular haemorrhagic lesions after the development of renal necrosis. The ocular pathology could be due to the immaturity of the ocular vasculature at this age. The hyaloid, choroid and retinal system are involved (AU)
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Collection:
National databases
/
Argentina
Database:
BINACIS
Main subject:
Eye Injuries
/
Choline Deficiency
/
Diet
/
Eye
/
Kidney Cortex Necrosis
/
Kidney Tubular Necrosis, Acute
Type of study:
Etiology study
Limits:
Animals
Language:
English
Journal:
Medicina (B.Aires)
Year:
2006
Document type:
Article
Institution/Affiliation country:
Hospital Británico/Argentina
/
Universidad de Buenos Aires/Argentina