Regional differences in astrocyte activation in HIV-associated dementia
Medicina (B.Aires)
; 66(2): 108-112, 2006. ilus, tab, graf
Article
in English
| BINACIS
| ID: bin-123452
Responsible library:
BR1.1
ABSTRACT
Since astrogliosis is a histological marker usually observed in HIV-associated dementia (HIV-D),we decided to investigate the potential relationship between the expression of glial fibrillary acidicprotein (GFAP) and the regional distribution of cells positive (+) for this specific marker of astrocyte activation.Histological sections of brain tissues obtained at necropsy from 5 HIV-D patients and 5 age-matched controlswithout history of neuropsychiatric illness were immunostained with peroxidase. Mean numbers of GFAP(+)astrocytes were significantly increased in entorhinal cortex, hippocampus and subcortical white matter of patients,but values in frontal cortex and basal ganglia were similar to those of controls. In contrast, surface density ofimmunoreactive GFAP was significantly increased in all tested brain areas from all patients, including unusuallyaffected regions such as entorhinal cortex and hippocampus. Therefore, such consistent finding of hypertrophicastrocytes, ranging from highest cell percentajes in subcortical white matter to lowest in basal ganglia indicatesthat quantification of surface density in GFAP (+) cells appears to be a more reliable approach to score gliosisthan the counting of their cell nuclei. Because astrocyte activation involves both protective and detrimental effectson adjacent neuronal subsets, the evidence of regional differences in this reactive potential highlights theimportance of accurately defining their contribution to the neuropathogenesis not only of HIV-D, but of a widerange of neurodegenerative disorders. (AU)
Full text:
Available
Collection:
National databases
/
Argentina
Health context:
SDG3 - Target 3.3 End transmission of communicable diseases
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
AIDS
/
Alzheimer’s Disease and other Dementias
/
Mental Health and Behavioral Disorders
Database:
BINACIS
Main subject:
Astrocytes
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AIDS Dementia Complex
/
Glial Fibrillary Acidic Protein
Type of study:
Etiology study
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Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Medicina (B.Aires)
Year:
2006
Document type:
Article
Institution/Affiliation country:
Hospital de Enfermedades Infecciosas Francisco J. Muñiz/Argentina
/
Univerdad de Buenos Aires/Argentina
/
Universidad de Buenos Aires/Argentina